The Spiritans arrived in Uganda in 1983. Their main ministry was centered around Mulago parish and Mulago hospital chaplaincy in Kampala Archdiocese. The first Uganda Spiritans belonged to the East African Province (Kenya, Tanzania and Uganda).  On October 2, 2008, the Uganda Foundation of the Congregation of the Holy Spirit was created by the Superior General comprising of 25 members.

Uganda is a landlocked country in East Africa. It is bordered on the east by Kenya, on the north by South Sudan, on the west by the Democratic Republic of the Congo, on the southwest by Rwanda, and on the south by Tanzania. With an estimated population of 36 million people, Uganda is the second most populous landlocked country.  About thirty-three percent of the population is Roman Catholic.

The Spiritans are engaged in HIV/AIDS ministry, educating school drop out girls, educating deaf children and ministering the sick especially at Mulago Hospital. The commitment to ministering to these marginalized people is an integral part of the Spiritan mission in Uganda.  Spiritans in Uganda also can be found working in parishes throughout the country including the Archdiocese of Kampala and the Dioceses of Hoima and Kabale.