Among their many and varied ministries, U.S. Spiritans place a great emphasis on education. They work in eight universities, two graduate programs of theological education, five secondary schools, and special educational ministry through Catholic Relief Services. At least 15 Spiritan priests are pursuing full-time graduate studies at American universities.

Spiritans in the U.S. serve in educational administration (at both the secondary and higher education levels), campus ministry and chaplaincy, counseling, and teaching including the University of San Diego, the University of Saint Thomas (Houston), the University of Houston, Texas Southern University (Houston), Notre Dame University (South Bend), Catholic University of America (Washington, DC), Salve Regina University (Providence), and Duquesne University (Pittsburgh).